iLIR provides easy integrated access to bioinformatics tools aiming to help researchers for assessing whether a protein is a potential functional LIR containing protein based solely on its amino acid sequence. A query sequence is analysed for:
- the presence of a generic, thus sensitive, extended LIR-motif (xLIR-motif), also scored against a PSSM constructed of experimentally validated set of LIR-motifs
- domain architecture based on SMART and PFAM, and
- predicted anchors, i.e. disordered linear segments with the potential to become ordered following protein interaction.
Results are displayed in a simple graphical form, accompanied with detailed tables. Examples of iLIR output for experimentally validated functional LIR containing proteins may be found in the
Examples Page.
Note: noncanonical LIR-motifs, as for example the atypical motif recently discovered in NDP52 (
von Muhlinen et al., 2012), are not currently detected by iLIR.
